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apple developer:Dutch health authorities to cancel 43,000 vaccination appointments

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,AstraZeneca's review, which covered more than 17 million people vaccinated in the United Kingdom and European Union, comes after health authorities in some countries suspended the use of its vaccine over clotting issues. AMSTERDAM: Dutch health authorities will be forced to cancel 43,000 vaccination appointments due to the government's decision to halt use of the Astrazeneca coronavirus vaccine for at least two weeks, news agency ANP reported Sunday. AstraZeneca Plc said on Sunday a review of safety data of people vaccinated with its COVID-19 vaccine has shown no evidence of an increased risk of blood clots. AstraZeneca's review, which covered more than 17 million people vaccinated in the United Kingdom and European Union, comes after health authorities in some countries suspended the use of its vaccine over clotting issues. "A careful review of all available safety data of more than 17 million people vaccinated in the European Union and UK with COVID-19 Vaccine AstraZeneca has shown no evidence of an increased risk of pulmonary embolism, deep vein thrombosis or thrombocytopenia, in any defined age group, gender, batch or in any particular country," the company said. Authorities in Ireland, Denmark, Norway, Iceland and the Netherlands have suspended the use of the vaccine over clotting issues, while Austria stopped using a batch of AstraZeneca shots last week while investigating a death from coagulation disorders. "It is most regrettable that countries have stopped vaccination on such 'precautionary' grounds: it risks doing real harm to the goal of vaccinating enough people to slow the spread of the virus, and to end the pandemic," Peter English, a retired British government consultant in communicable disease control, told Reuters. European Medicines Agency has said there is no indication that the events were caused by the vaccination, a view that was echoed by the World Health Organisation on Friday. The drugmaker said, 15 events of deep vein thrombosis and 22 events of pulmonary embolism have been reported so far, which is similar across other licensed COVID-19 vaccines. The company said additional testing has and is being conducted by the company and the European health authorities and none of the re-tests have shown cause for concern. The monthly safety report will be made public on the EMA website in the following week, AstraZeneca said. The AstraZeneca vaccine, developed in collaboration with Oxford University, has been authorised for use in the European Union and many countries but not yet by U.S. regulators. The company is preparing to file for U.S. emergency use authorisation and is expecting data from its U.S. Phase III trial to be available in the coming weeks. The move, which follows a similar decision by Ireland earlier in the day, is based on reports from Denmark and Norway of possible serious side effects, the government said. Three health workers in Norway who had recently received the vaccine were being treated in hospital for bleeding, blood clots and a low count of blood platelets, its health authorities said on Saturday. No such cases had been found yet in the Netherlands, the Dutch Health ministry said in a statement, adding that there was no proof yet of a direct link between the vaccine and the reports from Denmark and Norway. The government said it would now wait for an investigation by the European Medicines Agency (EMA). "We can't allow any doubts about the vaccine," Dutch Health minister Hugo de Jonge said. "We have to make sure everything is right, so it is wise to pause for now." The Dutch late last week said there was no reason to stop using the vaccine, following reports of the formation of blood clots in some people who had been injected with it. The EMA and the World Health Organisation have said there is no indication that these events were caused by the vaccination, and AstraZeneca has also said it had found no evidence of increased risk of deep-vein thrombosis. - Reuters
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